Beilstein J. Org. Chem.2018,14, 436–469, doi:10.3762/bjoc.14.32
this review, no application for controlling gene expression has been shown, but a certain potential in this field could be demonstrated. Additionally, other applications in different domains have been mentioned to extend the interest in such molecules.
Keywords: enzymolabile group; light-responsive
group; oligonucleotide prodrugs; reduction-responsive; stimuli-responsive nucleic acids; thermolytic prodrugs; Introduction
For past decades, oligonucleotide-based therapies have been widely developed using short synthetic oligonucleotides (ONs) and their chemically modified mimics as powerful tools to
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Graphical Abstract
Scheme 1:
Demasking under reducing agents of ON prodrugs modified as phosphotriesters with A) benzyl groups [13] ...